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公开(公告)号：EP2424840B1
公开(公告)日：2014-08-06
申请号：EP10715470.0
申请日：2010-04-26
发明人： KOWALSKI, Jennifer A. , MARSHALL, Daniel Richard , PROKOPOWICZ, Anthony S. III , SCHLYER, Sabine , SIBLEY, Robert , SORCEK, Ronald John , WU, Di , WU, Frank , YOUNG, Erick Richard Roush
IPC分类号： A61K31/495 , A61P29/00 , C07D403/12 , C07D401/14 , C07D491/08 , C07D213/74 , C07D217/00 , C07D317/68 , C07D319/18 , C07D231/10 , C07D233/90 , C07D235/04 , C07D413/12 , C07D417/12 , C07D471/12 , C07D295/185
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
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公开(公告)号：EP2590942B1
公开(公告)日：2016-05-04
申请号：EP11730533.4
申请日：2011-06-30
发明人： GINN, John David , MARSHALL, Daniel Richard , SIBLEY, Robert , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D207/09 , C07D217/22 , C07D277/60 , C07D401/12 , C07D417/12 , C07D417/14 , C07D513/04 , A61P9/00 , A61P25/00 , A61K31/437 , A61K31/5377 , A61K31/426 , A61K31/40
CPC分类号： C07D401/12 , C07D207/09 , C07D217/22 , C07D277/60 , C07D417/12 , C07D417/14 , C07D513/04
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公开(公告)号：EP2424840A1
公开(公告)日：2012-03-07
申请号：EP10715470.0
申请日：2010-04-26
发明人： KOWALSKI, Jennifer A. , MARSHALL, Daniel Richard , PROKOPOWICZ, Anthony S. III , SCHLYER, Sabine , SIBLEY, Robert , SORCEK, Ronald John , WU, Di , WU, Frank , YOUNG, Erick Richard Roush
IPC分类号： C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D307/68 , C07D317/68 , C07D319/18
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R
1 to R
5 , A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.-
4.发明公开N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS 有权的N-环基-3-（CYCLYLCARBONYLAMINOMETHYL）苯甲酰胺衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2590950A1
公开(公告)日：2013-05-15
申请号：EP11738871.0
申请日：2011-06-30
发明人： COOK, Brian Nicholas , KOWALSKI, Jennifer A. , LI, Xiang , MARSHALL, Daniel Richard , SCHLYER, Sabine , SIBLEY, Robert , SMITH-KEENAN, Lana Louise , SOLEYMANZADEH, Fariba , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K31/472 , A61P9/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) : and pharmaceutically acceptable salts thereof, wherein R
1 and R
2 are various ring systems. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase mediated diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.-
5.发明公开SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXAMIDE COMPOUNDS, THEIR PREPARATION AND USE 审中-公开取代的3-氨基噻吩并[2,3-b]吡啶-2-甲酰胺化合物及其制备和用途
公开(公告)号：EP2029608A1
公开(公告)日：2009-03-04
申请号：EP07797918.5
申请日：2007-05-31
IPC分类号： C07D495/04 , A61K31/4365 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D495/04
摘要： Disclosed are compounds of formula (I): (I) wherein R
1 and R
4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.-
6.发明授权N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS 有权的N-环基-3-（CYCLYLCARBONYLAMINOMETHYL）苯甲酰胺衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2590950B1
公开(公告)日：2014-10-15
申请号：EP11738871.0
申请日：2011-06-30
发明人： COOK, Brian Nicholas , KOWALSKI, Jennifer A. , LI, Xiang , MARSHALL, Daniel Richard , SCHLYER, Sabine , SIBLEY, Robert , SMITH-KEENAN, Lana Louise , SOLEYMANZADEH, Fariba , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K31/472 , A61P9/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP2590942A1
公开(公告)日：2013-05-15
申请号：EP11730533.4
申请日：2011-06-30
发明人： GINN, John David , MARSHALL, Daniel Richard , SIBLEY, Robert , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D207/09 , C07D217/22 , C07D277/60 , C07D401/12 , C07D417/12 , C07D417/14 , C07D513/04 , A61P9/00 , A61P25/00 , A61K31/437 , A61K31/5377 , A61K31/426 , A61K31/40
CPC分类号： C07D401/12 , C07D207/09 , C07D217/22 , C07D277/60 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R
1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase-mediated disorders selected from hypertension, atherosclerosis, restenosis, stroke, myocardial infarction, heart failure, coronary artery disease, peripheral artery disease, coronary vasospasm, cerebral vasospasm, ischemia/reperfusion injury, pulmonary hypertension, angina, erectile dysfunction, renal disease, organ failure, asthma, glaucoma, cancer, Alzheimer's disease, multiple sclerosis, spinal cord injury, neuropathic pain, rheumatoid arthritis, psoriasis inflammatory bowel disease, and combinations of such disorders.
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