发明公开
- 专利标题： ONCOLYTIC MEASLES VIRUS
- 专利标题（中）： 溶瘤麻疹病毒
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申请号： EP11748282.8申请日： 2011-08-19
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公开(公告)号： EP2605783A1公开(公告)日： 2013-06-26
- 发明人: Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
- 申请人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
- 申请人地址： Rammertstraße 43 72072 Tübingen DE
- 专利权人： Lauer, Ulrich M.,Bitzer, Michael,Lampe, Johanna,Zimmermann, Martina,Berchtold, Susanne,Lange, Sebastian,Neubert, Wolfgang J.,Bossow, Sascha
- 当前专利权人： Lauer, Ulrich M.,Bitzer, Michael,Lampe, Johanna,Zimmermann, Martina,Berchtold, Susanne,Lange, Sebastian,Neubert, Wolfgang J.,Bossow, Sascha
- 当前专利权人地址： Rammertstraße 43 72072 Tübingen DE
- 代理机构： Ricker, Mathias
- 优先权： EP10008726 20100820
- 国际公布： WO2012022495 20120223
- 主分类号： A61K35/76
- IPC分类号： A61K35/76 ; C12N15/45 ; A61P35/00 ; C12N9/10 ; C12N9/78 ; C07K19/00
摘要：
The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
公开/授权文献
- EP2605783B1 ONCOLYTIC MEASLES VIRUS 公开/授权日：2015-03-25
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