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公开(公告)号：EP2605783A1
公开(公告)日：2013-06-26
申请号：EP11748282.8
申请日：2011-08-19
申请人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
发明人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
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公开(公告)号：EP2605783B1
公开(公告)日：2015-03-25
申请号：EP11748282.8
申请日：2011-08-19
申请人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
发明人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang J. , Bossow, Sascha
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
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公开(公告)号：EP2420242A1
公开(公告)日：2012-02-22
申请号：EP10008726.1
申请日：2010-08-20
申请人： Lauer, Ulrich M. , Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang , Bossow, Sascha
发明人： Bitzer, Michael , Lampe, Johanna , Zimmermann, Martina , Berchtold, Susanne , Lange, Sebastian , Neubert, Wolfgang , Bossow, Sascha
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
摘要翻译： 本发明涉及一种药物组合物，其包含编码自杀基因的重组麻疹病毒，所述重组麻疹病毒用于治疗对具有无自杀基因活性的溶瘤麻疹病毒的一级或二级抗性的恶性细胞。 此外，本发明涉及一种基于编码自杀基因的麻疹疫苗株Schwarz的重组麻疹病毒，其包含胞嘧啶脱氨酶，特别是酵母胞嘧啶脱氨酶和尿嘧啶磷酸核糖转移酶，特别是酵母尿嘧啶磷酸核糖转移酶的融合， 用于制备本文所要求的重组麻疹病毒的试剂盒。
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