发明公开
EP2606139A2 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE
有权
生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
- 专利标题： BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE
- 专利标题（中）： 生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
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申请号： EP11818555.2申请日： 2011-08-08
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公开(公告)号： EP2606139A2公开(公告)日： 2013-06-26
- 发明人: CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
- 申请人： Codexis, Inc. , Cabirol, Fabien L. , Gohel, Anupam , Collier, Steven J. , Liang, Jack , Mock, Marissa , Mundorff, Emily , Novick, Scott , Limanto, John , Smith, Derek , Beutner, Gregory , Klapars, Artis , Ashley, Eric , Strotman, Hallena , Truppo, Matthew , Hughes, Gregory , Grau, Brendan , Janey, Jacob
- 申请人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 专利权人： Codexis, Inc.,Cabirol, Fabien L.,Gohel, Anupam,Collier, Steven J.,Liang, Jack,Mock, Marissa,Mundorff, Emily,Novick, Scott,Limanto, John,Smith, Derek,Beutner, Gregory,Klapars, Artis,Ashley, Eric,Strotman, Hallena,Truppo, Matthew,Hughes, Gregory,Grau, Brendan,Janey, Jacob
- 当前专利权人： Codexis, Inc.,Cabirol, Fabien L.,Gohel, Anupam,Collier, Steven J.,Liang, Jack,Mock, Marissa,Mundorff, Emily,Novick, Scott,Limanto, John,Smith, Derek,Beutner, Gregory,Klapars, Artis,Ashley, Eric,Strotman, Hallena,Truppo, Matthew,Hughes, Gregory,Grau, Brendan,Janey, Jacob
- 当前专利权人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 代理机构： Carpmaels & Ransford
- 优先权： US201161510256P 20110721; US374079P 20100816
- 国际公布： WO2012024104 20120223
- 主分类号： C12P13/00
- IPC分类号： C12P13/00 ; C12P7/00
摘要：
The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
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