发明公开
EP2606897A1 Methods and compositions for the treatment of diseases caused by enveloped viruses
审中-公开
方法和组合物用于由包膜病毒引起的疾病的治疗
- 专利标题： Methods and compositions for the treatment of diseases caused by enveloped viruses
- 专利标题（中）： 方法和组合物用于由包膜病毒引起的疾病的治疗
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申请号： EP11382392.6申请日： 2011-12-22
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公开(公告)号： EP2606897A1公开(公告)日： 2013-06-26
- 发明人: Izquierdo Useros, Núria , Kraüsslich, Hans-Georg , Lorizate, Maier , Martínez Picado, Javier
- 申请人： Laboratorios del. Dr. Esteve, S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana De Recerca I Estudis Avançats (ICREA)
- 申请人地址： Avda. Mare de Déu de Montserrat 221 08041 Barcelona ES
- 专利权人： Laboratorios del. Dr. Esteve, S.A.,Fundació Privada Institut de Recerca de la SIDA-Caixa,Institució Catalana De Recerca I Estudis Avançats (ICREA)
- 当前专利权人： Laboratorios del. Dr. Esteve, S.A.,Fundació Privada Institut de Recerca de la SIDA-Caixa,Institució Catalana De Recerca I Estudis Avançats (ICREA)
- 当前专利权人地址： Avda. Mare de Déu de Montserrat 221 08041 Barcelona ES
- 代理机构： ABG Patentes, S.L.
- 主分类号： A61K31/7016
- IPC分类号： A61K31/7016 ; A61P31/12 ; A61P31/18 ; G01N33/569
摘要：
The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.
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