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公开(公告)号：EP4059956A1
公开(公告)日：2022-09-21
申请号：EP22152377.2
申请日：2016-11-19
IPC分类号： C07K14/73 , C07K14/715 , A61P31/18 , A61K39/395
摘要： The present invention relates to antibody derivatives against HIV based on a mutated CD4-IgG scaffold with enhanced antiviral and immunomodulatory activities. These antibody derivatives are characterized for having an increased ability to (i) block the entry of human immunodeficiency virus (HIV) into host cells and (ii) elicit effector functions through the activation of natural killer (NK) cells. The present invention further relates to nucleic acids, vectors and host cells expressing said antibody derivatives, as well their therapeutic and diagnostic applications in human health.
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2.发明公开
公开(公告)号：EP3490596A2
公开(公告)日：2019-06-05
申请号：EP17778329.7
申请日：2017-07-26
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公开(公告)号：EP3205662A3
公开(公告)日：2017-11-01
申请号：EP17162645.0
申请日：2011-11-10
申请人： Laboratorios del Dr. Esteve S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats , University of Washington
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
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公开(公告)号：EP3205662A2
公开(公告)日：2017-08-16
申请号：EP17162645.0
申请日：2011-11-10
申请人： Laboratorios del Dr. Esteve S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana de Recerca i Estudis Avançats , University of Washington
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/572 , C07K7/08 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16034 , C12N2740/16071 , C12N2740/16222 , C12N2740/16234 , G01N33/505 , G01N2333/161
摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
摘要翻译： 本发明涉及包含衍生自天然存在的HIV变体编码的多肽家族的中心树（COT）序列内的部分或全部保守元件的肽。 本发明还涉及包含所述肽的免疫原性组合物和疫苗。 本发明还涉及基于检测患者的T细胞以产生针对所述肽的细胞毒性T细胞应答来鉴定HIV控制患者的方法，以及鉴定变体多肽家族内的免疫原性肽的方法。
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5.发明公开VSV-HIV viral particles lacking reverse transcriptase functionality and therapeutic applications thereof 审中-公开VSV-HIV-Virenpartikel mit Mangel anUmkehrtranskriptasefunktionalitätund therapeutische Anwendungen davon
公开(公告)号：EP2703482A1
公开(公告)日：2014-03-05
申请号：EP12382340.3
申请日：2012-09-04
CPC分类号： C12N7/00 , C12N2740/15021 , C12N2740/15034 , C12N2740/15062 , C12N2810/6081
摘要： The present invention relates to the development of non-replicative virions comprising a human immunodeficiency virus (HIV) genome and vehiculized by the G protein of a vesicular stomatitis virus (VSV). Said virions are useful in medicine, specifically for use in generating vaccines and more specifically for treating AIDS. The present invention further relates to a method for obtaining a customized vaccine.
摘要翻译： 本发明涉及包含人免疫缺陷病毒（HIV）基因组和由水泡性口炎病毒（VSV）的G蛋白车辆化的非复制病毒粒子的开发。 所述病毒粒子可用于医药，特别用于产生疫苗，更具体地用于治疗AIDS。 本发明还涉及获得定制疫苗的方法。
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6.发明公开Enhanced rapid immunogen selection method for HIV gp120 variants 审中-公开Verbessertes schnelles Immunogene AuswahlverfahrenfürHIV gp120 Varianten
公开(公告)号：EP2698377A1
公开(公告)日：2014-02-19
申请号：EP12382328.8
申请日：2012-08-17
IPC分类号： C07K14/16 , A61K39/21 , G01N33/569 , G01N33/68
CPC分类号： C12N15/1055 , A61K39/00 , A61K2039/575 , C07K14/005 , C07K16/1063 , C12N7/00 , C12N2740/16043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12Q1/6874 , G01N33/56988 , G01N2333/162 , G01N2500/04
摘要： The invention relates to an enhanced method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized variants of a surface polypeptide displayed to said neutralizing antibodies. HIV gp120 has been used as immuonogen. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
摘要翻译： 本发明涉及一种用于快速免疫原选择（RIS）的增强方法，其基于结合包含显示给所述中和抗体的表面多肽的随机化变体的重组病毒文库。 HIV gp120已被用作免疫原。 本发明还涉及根据本发明的RIS方法分离的HIV gp120免疫原在药物中的用途，用于治疗由病毒引起的疾病并用于诊断患者中的中和抗体。
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7.发明公开USE OF GROWTH HORMONE TO ENHANCE THE IMMUNE RESPONSE IN IMMUNOSUPPRESSED PATIENTS 审中-公开生长激素，可改善免疫抑制患者的免疫反应
公开(公告)号：EP2621518A2
公开(公告)日：2013-08-07
申请号：EP11763687.8
申请日：2011-09-29
申请人： Laboratorios del. Dr. Esteve, S.A. , Fundació Privada Institut de Recerca de la SIDA-Caixa , Institució Catalana De Recerca I Estudis Avançats (ICREA)
CPC分类号： A61K38/27 , Y02A50/463
摘要： The present invention relates to a method for stimulating the recovery of cellular and humoral responses in vivo based on growth hormone.
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公开(公告)号：EP4163290A1
公开(公告)日：2023-04-12
申请号：EP22195110.6
申请日：2013-01-28
摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
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公开(公告)号：EP2678351B1
公开(公告)日：2017-09-13
申请号：EP12705689.3
申请日：2012-02-24
IPC分类号： C07K14/16 , A61K39/21 , G01N33/569 , G01N33/68 , C12N15/10
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1063 , C07K2317/76 , C12N15/1037 , C12N2740/16043 , C12N2740/16122 , C12N2799/027 , G01N33/56988 , G01N33/6854 , G01N2333/162 , G01N2469/20
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公开(公告)号：EP2678351A1
公开(公告)日：2014-01-01
申请号：EP12705689.3
申请日：2012-02-24
IPC分类号： C07K14/16 , A61K39/21 , G01N33/569 , G01N33/68 , C12N15/10
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1063 , C07K2317/76 , C12N15/1037 , C12N2740/16043 , C12N2740/16122 , C12N2799/027 , G01N33/56988 , G01N33/6854 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
摘要翻译： 本发明涉及一种基于结合包含显示给所述中和抗体的表面多肽的随机HIV gp120变体的重组病毒文库的快速免疫原选择（RIS）的方法。 本发明还涉及根据本发明的RIS方法分离的HIV gp120免疫原在医学上用于治疗由病毒引起的疾病和诊断用于鉴定患者中的中和抗体的用途。
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