发明公开
EP2638025A2 CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS
审中-公开
铬衍生物和类似物AS WNT信号拮抗剂
- 专利标题： CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS
- 专利标题（中）： 铬衍生物和类似物AS WNT信号拮抗剂
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申请号： EP11785375.4申请日： 2011-11-11
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公开(公告)号： EP2638025A2公开(公告)日： 2013-09-18
- 发明人: BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
- 申请人： Deutsches Krebsforschungszentrum (DKFZ) , Ruprecht-Karls-Universität Heidelberg
- 申请人地址： Im Neuenheimer Feld 280 69120 Heidelberg DE
- 专利权人： Deutsches Krebsforschungszentrum (DKFZ),Ruprecht-Karls-Universität Heidelberg
- 当前专利权人： Deutsches Krebsforschungszentrum (DKFZ),Ruprecht-Karls-Universität Heidelberg
- 当前专利权人地址： Im Neuenheimer Feld 280 69120 Heidelberg DE
- 代理机构： Büchel, Edwin
- 优先权： EP10191072 20101112
- 国际公布： WO2012062901 20120518
- 主分类号： C07D311/96
- IPC分类号： C07D311/96 ; C07D413/04 ; C07D491/04 ; C07D493/04 ; A61K31/352 ; A61K31/436 ; A61K31/4741 ; A61P35/00
摘要：
Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
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