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公开(公告)号：EP2638026B1
公开(公告)日：2018-07-11
申请号：EP11785376.2
申请日：2011-11-11
发明人： BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
IPC分类号： C07D311/96 , C07D413/04 , C07D491/04 , C07D493/04 , A61K31/352 , A61K31/436 , A61K31/4741 , A61K31/519 , A61P35/00
CPC分类号： C07D311/92 , C07D311/04 , C07D311/96 , C07D413/04 , C07D491/04 , C07D491/052 , C07D493/04
摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
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公开(公告)号：EP2638025B1
公开(公告)日：2020-02-05
申请号：EP11785375.4
申请日：2011-11-11
发明人： BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
IPC分类号： C07D311/96 , C07D413/04 , C07D491/04 , C07D493/04 , A61K31/352 , A61K31/436 , A61K31/4741 , A61P35/00
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公开(公告)号：EP2638025A2
公开(公告)日：2013-09-18
申请号：EP11785375.4
申请日：2011-11-11
发明人： BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
IPC分类号： C07D311/96 , C07D413/04 , C07D491/04 , C07D493/04 , A61K31/352 , A61K31/436 , A61K31/4741 , A61P35/00
摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
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公开(公告)号：EP2638026A2
公开(公告)日：2013-09-18
申请号：EP11785376.2
申请日：2011-11-11
发明人： BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
IPC分类号： C07D311/96 , C07D413/04 , C07D491/04 , C07D493/04 , A61K31/352 , A61K31/436 , A61K31/4741 , A61K31/519 , A61P35/00
CPC分类号： C07D311/92 , C07D311/04 , C07D311/96 , C07D413/04 , C07D491/04 , C07D491/052 , C07D493/04
摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
摘要翻译： 式（IIc）化合物; 其中X3和X4彼此独立地是N或CR8，其中R8可以相同或不同; Y1，Y2，Y3和Y4彼此独立地是N或CR9，其中R9可以相同或不同，并且其中Y1，Y2，Y3和Y4中的至多3个可以是N; 其溶剂合物，水合物和药学上可接受的盐，它们用于调节Wnt信号传导途径活性及其作为药物的用途的用途，优选用于治疗癌症。
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