发明公开
- 专利标题： Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
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申请号： EP13151352.5申请日： 2008-08-22
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公开(公告)号： EP2641917A2公开(公告)日： 2013-09-25
- 发明人: Jackson, Simon Mark , Walker, Nigel Pelham Clinton , Piper, Derek Evan , Shan, Bei , Shen, Wenyan , Chan, Joyce Chi Yee , King, Chadwick Terence , Ketchem, Randal Robert , Mehlin, Christopher , Carabeo, Teresa Arazas , Cao, Qiong
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构： Dörries, Hans Ulrich
- 优先权： US86133P 20080804
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; A61P3/06 ; A61K39/395
摘要：
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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