公开(公告)号：EP2641917B1

公开(公告)日：2020-05-06

申请号：EP13151352.5

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/505 ,  A61K31/66 ,  A61K31/47 ,  A61K39/00

公开(公告)号：EP2615114A3

公开(公告)日：2013-11-20

申请号：EP13151375.6

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

摘要翻译： 描述了与Prop蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其他病症的方法。 描述了使用针对PCSK9的抗原结合蛋白检测样品中PCSK9的量的方法。

公开(公告)号：EP2641917A3

公开(公告)日：2014-02-19

申请号：EP13151352.5

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/505 ,  A61K31/66 ,  A61K31/47 ,  A61K39/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2641918A2

公开(公告)日：2013-09-25

申请号：EP13151381.4

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2615113A3

公开(公告)日：2013-11-13

申请号：EP13151343.4

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

摘要翻译： 描述了与Proprotein转氨酶枯草杆菌蛋白酶Kexin 9型（PCSK9）相互作用的抗原结合蛋白。 描述了通过向PCSK9施用药学有效量的抗原结合蛋白来治疗高胆固醇血症和其它病症的方法。 描述使用抗原结合蛋白向PCSK9检测样品中PCSK9的量的方法。

公开(公告)号：EP2615113A2

公开(公告)日：2013-07-17

申请号：EP13151343.4

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2641918A3

公开(公告)日：2014-03-05

申请号：EP13151381.4

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395 ,  A61K45/06 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2641917A2

公开(公告)日：2013-09-25

申请号：EP13151352.5

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：EP2615114A2

公开(公告)日：2013-07-17

申请号：EP13151375.6

申请日：2008-08-22

申请人： Amgen Inc.

发明人： Jackson, Simon Mark ,  Walker, Nigel Pelham Clinton ,  Piper, Derek Evan ,  Shan, Bei ,  Shen, Wenyan ,  Chan, Joyce Chi Yee ,  King, Chadwick Terence ,  Ketchem, Randal Robert ,  Mehlin, Christopher ,  Carabeo, Teresa Arazas ,  Cao, Qiong

IPC分类号： C07K16/40 ,  A61P3/06 ,  A61K39/395

CPC分类号： C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.