发明公开
EP2662453A2 Detection and treatment of schizophrenia
审中-公开
Nachweis und Behandlung von Schizophrenie
- 专利标题： Detection and treatment of schizophrenia
- 专利标题（中）： Nachweis und Behandlung von Schizophrenie
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申请号： EP13003496.0申请日： 2008-07-31
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公开(公告)号： EP2662453A2公开(公告)日： 2013-11-13
- 发明人: Itokawa, Masanari , Miyata, Toshio , Arai, Makoto
- 申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM , Tokyo Metropolitan Institute of Medical Science , Renascience CO., LTD. , Medical and Biological Laboratories Co., Ltd.
- 申请人地址： 28-4, Tomigaya 2-chome Shibuya-ku Tokyo 1510063 JP
- 专利权人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM,Tokyo Metropolitan Institute of Medical Science,Renascience CO., LTD.,Medical and Biological Laboratories Co., Ltd.
- 当前专利权人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM,Tokyo Metropolitan Institute of Medical Science,Renascience CO., LTD.,Medical and Biological Laboratories Co., Ltd.
- 当前专利权人地址： 28-4, Tomigaya 2-chome Shibuya-ku Tokyo 1510063 JP
- 代理机构： Müller-Boré & Partner Patentanwälte
- 优先权： JP2007214047 20070820
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A61K31/415 ; A61K31/4152 ; A61K31/437 ; A61K31/4415 ; A61K31/4439 ; A61K45/00 ; A61P25/18 ; C12N15/09 ; G01N30/88 ; G01N33/15
摘要：
The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a biological sample. The present further relates to a primer, a probe and a reagent for use in said method, as well as an AGE-reader and its use for measuring the amount of carbonyl-modified proteins.
公开/授权文献
- EP2662453A3 Detection and treatment of schizophrenia 公开/授权日：2014-02-26
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