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公开(公告)号：EP4431105A1
公开(公告)日：2024-09-18
申请号：EP22892849.5
申请日：2022-11-10
Applicant: KJ Bio Co., Ltd. , TOKAI UNIVERSITY EDUCATIONAL SYSTEM
Inventor： KUNO, Hitoshi , KANNO, Akiko , KOMATSU, Satoko , KAMETANI, Yoshie , OHSHIMA, Shino , OHNO, Yusuke
CPC classification number: A23K10/30 , A23L33/10 , A61K8/9722 , A61K36/05 , A61P37/04 , A61P43/00 , A61Q19/00 , C12N1/12
Abstract: It is an object of the present invention to provide a means capable of appropriately regulating differentiation of T cells, in order to avoid overactivation of T cells after stimulation of the T cells with superantigens or the like and the subsequent decrease in the immune functions (exhaustion of the immune system). The present invention relates to a T cell differentiation-regulating agent, comprising, as an active ingredient, an algal body of microalgae belonging to the genus Coccomyxa, a dry powder thereof, or an extract thereof.
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2.发明公开
公开(公告)号：EP4144835A1
公开(公告)日：2023-03-08
申请号：EP21797636.4
申请日：2021-04-26
Inventor： SAKAI, Daisuke , NAKAMURA, Yoshihiko , MATSUSHITA, Erika
Abstract: The present invention provides a means for efficiently preparing a cell population rich in functional chondrocytes that produce an extracellular matrix such as type II collagen. This culture method according to the present invention involves a method of culturing a cell population containing cartilage-derived cells positive for expression of Tie2 (cartilage-derived Tie2-positive cells), the method comprising culturing a cell population containing cartilage-derived Tie2-positive cells in a culture medium containing at least one kind of Tie2 expression enhancer other than growth factors (e.g., an extract derived from a plant of the genus Cinnamomum). This culturing method is preferably performed in cultureware having a culture surface coated with a coating agent (e.g., a polylysine-containing agent).
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公开(公告)号：EP3997211A1
公开(公告)日：2022-05-18
申请号：EP21755088.8
申请日：2021-07-29
Applicant: Tokai University Educational System
Inventor： SAKAI, Daisuke , SCHOL, Jordy , NAKAMURA, Yoshihiko
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4.发明公开
公开(公告)号：EP3985378A1
公开(公告)日：2022-04-20
申请号：EP20821992.3
申请日：2020-05-20
Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM
Inventor： OKAMURA Yosuke , ZHANG Hong , KITA Rio , KIMURA Hiroshi
IPC: G01N1/28
Abstract: An observation sample covering implement (10) is provided with an ultra-thin film (1) for covering an observation sample, and a main body portion (2) including a holding portion (3) having opening portion (4) formed therein, characterized in that: the ultra-thin film (1) is formed to be larger than the opening portion (4); and the ultra-thin film (1) is held onto the holding portion (3) by being stuck by physical adsorption to at least an upper surface and a portion of a side surface of the holding portion (3) in such a way as to close the opening portion (4).
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5.发明公开
公开(公告)号：EP3859754A1
公开(公告)日：2021-08-04
申请号：EP19865613.4
申请日：2019-09-20
Inventor： SUGIMOTO, Masahiro , TSUBOUCHI, Hirokazu , ASAMI, Daisuke , II, Hideki , AWAJI, Satoshi , OGURO, Hidetoshi
Abstract: The present invention provides: a compound superconducting twisted wire in which non-adhesiveness between compound superconducting strands or separation easiness after adhesion is improved while a strength against tension is improved to a degree to be equivalent to or stronger than that of a conventional compound superconducting twisted wire; and a rewinding method thereof. The compound superconducting twisted wire 1 of the present invention includes a plurality of compound superconducting strands 10 being twisted to form a twisted structure, in which each of the compound superconducting strands 10 includes a compound superconductor part 11, a reinforcing part 12 and a stabilizing part 13, in which the compound superconductor part 11 includes a plurality of compound superconducting filaments 15 and a first matrix 16, the compound superconducting filaments 15 each including a compound superconducting phase, in which the reinforcing part 12 is disposed on an outer circumferential side of the compound superconductor part, and comprises a plurality of reinforcing filaments 18 and a second matrix 19, in which the stabilizing part 13 is disposed on at least one side of an inner circumferential side and an outer circumferential side of the reinforcing part. In the compound superconducting twisted wire, a volume ratio of the reinforcing part relative to the compound superconducting strand is larger than a volume ratio of the compound superconductor part relative to the compound superconducting strand, or a metal layer 20 with a thickness of 2 µm or less is formed on a surface of the compound superconducting strand for preventing thermal fusion between the compound superconducting strands.
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Patent Agency Ranking
公开(公告)号：EP3647775A1
公开(公告)日：2020-05-06
申请号：EP18822823.3
申请日：2018-05-18
Applicant: Tokai University Educational System
Inventor： AZETSU, Akihiko , KITAJIMA, Ikkei , KURATSUJI, Kazaki , OCHIAI, Masayuki
Abstract: According to the present invention, a measurement method for visualizing the flow of a fluid (23) has: a preparation step for dissolving, in the fluid (23), a photochromic compound of which the amount of light absorption changes when the photochromic compound is irradiated with a transformation-generating light (31); a transformation-generating light irradiating step for irradiating the fluid (23) with the transformation-generating light (31) that causes photochromism; and a post-transformation image capturing step for capturing an image of the fluid (23) irradiated with the transformation-generating light. In the post-transformation image capturing step, a first image (B) is generated by capturing the image of the fluid (23) using first light in a first wavelength range, wherein the amount of light absorption of the first light changes due to the irradiation of the transformation-generating light (31).
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公开(公告)号：EP3578682A1
公开(公告)日：2019-12-11
申请号：EP18748656.8
申请日：2018-01-30
Applicant: Tokai University Educational System , Shincron Co., Ltd.
Inventor： MUROTANI, Hiroshi , HORIGUCHI, Yukio , SUGAWARA, Takuya
Abstract: Provided is a film-formation method for a surface layer having high mechanical strength and a low refractive index. A step of film formation from a vapor deposition material by a vacuum vapor deposition method and a step of film formation by sputtering of a target constituent substance are repeated for the surfaces of substrates (S), thereby forming films with a lower refractive index than that of a film-forming material.
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公开(公告)号：EP3527215A1
公开(公告)日：2019-08-21
申请号：EP19158239.4
申请日：2019-02-20
Inventor： Sakai, Daisuke , Nakai, Tomoko , Naiki, Mitsuru , Shibayama, Yoji
Abstract: An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.
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公开(公告)号：EP3135315A1
公开(公告)日：2017-03-01
申请号：EP15783466.4
申请日：2015-04-20
Inventor： OKAMURA, Yosuke , NAGASE, Yu , KOMACHI, Takuya , HOCHI, Motonori , SEKIDO, Yuki , ARAKANE, Toru
CPC classification number: A61L31/00 , A61L15/16 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/148 , A61L2400/12 , B32B7/045 , B32B9/02 , B32B9/04 , B32B9/045 , B32B27/08 , B32B27/306 , B32B27/36 , B32B2250/05 , B32B2250/24 , B32B2250/44 , B32B2307/7163 , B32B2307/73 , B32B2535/00 , C08L67/04 , C08L5/04 , C08L29/04
Abstract: The present invention provides a polymer laminate in which 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. By the present invention, a polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
Abstract translation: 本发明提供一种聚合物层叠体，其中层叠2〜100层各自含有生物降解性树脂，厚度为10nm〜400nm的聚合物层叠体，至少一层最外层的厚度为10nm〜180nm， 最外层彼此连接。 通过本发明，可以获得生物相容性和机械强度优异且适用于医疗用途如伤口敷料和防粘附材料的聚合物层压体。
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10.发明公开
公开(公告)号：EP2735314A1
公开(公告)日：2014-05-28
申请号：EP12779704.1
申请日：2012-05-01
Applicant: BioMedCore Inc. , Sapporo Medical University , Tokai University Educational System , Torigoe, Toshihiko , Sato, Noriyuki
Inventor： KAJIWARA, Toshimitsu , NUMAZAKI, Maki , SHIMIZU, Yoshitaka , TAMURA, Yasuaki , KOJIMA, Naoya
IPC: A61K39/39 , A61K9/127 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K47/36 , A61K48/00 , A61P35/00 , C07K14/705
CPC classification number: A61K31/7088 , A61K9/1271 , A61K39/0011 , A61K39/39 , A61K47/6911 , A61K2039/55555
Abstract: [Problem] The purpose of the present invention is to provide a preparation which has an effect of further promoting cellular immunity when used in an adjuvant or in a method for removing an immunosuppression mechanism.
[Solution] Provided is a sugar-coated liposome (particularly a mannose-coated liposome) which can activate a CTL in an MHC-class II antigen-independent (CD4+T cell-independent) manner when administered together with an MHC class I antigen. Particularly provided is a sugar-coated liposome which has a particle diameter of 100-1100 nm and/or in which the molar ratio of a sugar-modified lipid to a lipid is 0.00075-0.075.Abstract translation: 本发明的目的在于提供一种在佐剂中使用时具有进一步促进细胞免疫的作用的制剂，或者是除去免疫抑制机理的方法。 [解决方案]提供了当与MHC I类抗原一起施用时，可以激活MHC-II类抗原非依赖性（CD4 + T细胞非依赖性）方式的CTL的糖包衣脂质体（特别是甘露糖包被的脂质体） 。 特别提供的是具有100-1100nm粒径和/或其中糖改性脂质与脂质的摩尔比为0.00075-0.075的糖衣脂质体。
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