- 专利标题： SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS
- 专利标题（中）： 替代氨苄西泮胺
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申请号： EP12708194.1申请日： 2012-02-16
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公开(公告)号： EP2675795B1公开(公告)日： 2016-04-20
- 发明人: FLEURY, Melissa , GENDRON, Roland , HUGHES, Adam D.
- 申请人： Theravance Biopharma R&D IP, LLC
- 申请人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Scott, Susan Margaret
- 优先权： US201161443827P 20110217
- 国际公布： WO2012112742 20120823
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; C07D249/10 ; C07D249/18 ; C07D261/12 ; C07D471/04 ; C07C233/46 ; C07C233/47 ; A61K31/415 ; A61K31/4164 ; A61K31/4192 ; A61K31/4196 ; A61K31/42 ; A61K31/405 ; A61P9/00 ; A61P13/00 ; C07D235/08 ; C07D309/40
摘要：
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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