发明授权
EP2675821B1 PREGNANOLONE DERIVATIVES SUBSTITUTED IN 3ALPHA-POSITION WITH THE CATIONIC GROUP, USAGE AND PHARMACEUTICAL PREPARATION INVOLVING THEM
有权
在阳离子基团取代的孕烯醇酮衍生物，涉及它们的阳离子基团，用途和药物制剂
- 专利标题： PREGNANOLONE DERIVATIVES SUBSTITUTED IN 3ALPHA-POSITION WITH THE CATIONIC GROUP, USAGE AND PHARMACEUTICAL PREPARATION INVOLVING THEM
- 专利标题（中）： 在阳离子基团取代的孕烯醇酮衍生物，涉及它们的阳离子基团，用途和药物制剂
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申请号： EP12711108.6申请日： 2012-02-15
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公开(公告)号： EP2675821B1公开(公告)日： 2018-04-18
- 发明人: CHODOUNSKÁ, Hana , KAPRAS, Vojtech , VYKLICKY, Ladislav , BOROVSKÁ, Jirina , VYKLICKY, Vojtech , VALES , Karel , STUCHLÍK, Ales , RAMBOUSEK, Lukás
- 申请人： Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i. , Fyziologicky Ústav Akademie VED Ceské Republiky, V.V.I.
- 申请人地址： Flemingovo námesti 2 166 10 Praha 6 CZ
- 专利权人： Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i.,Fyziologicky Ústav Akademie VED Ceské Republiky, V.V.I.
- 当前专利权人： Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i.,Fyziologicky Ústav Akademie VED Ceské Republiky, V.V.I.
- 当前专利权人地址： Flemingovo námesti 2 166 10 Praha 6 CZ
- 代理机构： Herman, Vaclav
- 优先权： CZ20110081 20110215
- 国际公布： WO2012110010 20120823
- 主分类号： C07J41/00
- IPC分类号： C07J41/00 ; C07J75/00 ; A61K31/57 ; A61P25/00 ; A61P25/24 ; A61P25/28
摘要：
Pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, and a method of the production of these compounds and their utilization for treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post traumatic stress disorder, and other diseases related to stress, anxiety, schizophrenia, and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy, and gliomas. The compounds are also used for production of veterinary and human pharmaceutical preparation for treatment of above mentioned diseases and for production of pharmaceutical preparations containing these compounds.
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