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1.发明授权PREGNANOLONE DERIVATIVES SUBSTITUTED IN 3ALPHA-POSITION WITH THE CATIONIC GROUP, USAGE AND PHARMACEUTICAL PREPARATION INVOLVING THEM 有权在阳离子基团取代的孕烯醇酮衍生物，涉及它们的阳离子基团，用途和药物制剂
公开(公告)号：EP2675821B1
公开(公告)日：2018-04-18
申请号：EP12711108.6
申请日：2012-02-15
申请人： Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i. , Fyziologicky Ústav Akademie VED Ceské Republiky, V.V.I.
发明人： CHODOUNSKÁ, Hana , KAPRAS, Vojtech , VYKLICKY, Ladislav , BOROVSKÁ, Jirina , VYKLICKY, Vojtech , VALES , Karel , STUCHLÍK, Ales , RAMBOUSEK, Lukás
CPC分类号： C07J41/0011 , C07J41/0005 , C07J41/005
摘要： Pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, and a method of the production of these compounds and their utilization for treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post traumatic stress disorder, and other diseases related to stress, anxiety, schizophrenia, and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy, and gliomas. The compounds are also used for production of veterinary and human pharmaceutical preparation for treatment of above mentioned diseases and for production of pharmaceutical preparations containing these compounds.
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2.发明公开PREGNANOLONE DERIVATIVES SUBSTITUTED IN 3ALPHA-POSITION WITH THE CATIONIC GROUP, METHOD OF THEIR PRODUCTION, USAGE AND PHARMACEUTICAL PREPARATION INVOLVING THEM 有权在3ALPHA位取代PREGNANOLONDERIVATE用阳离子GROUP，方法制作，以便在使用和药物研制
公开(公告)号：EP2675821A1
公开(公告)日：2013-12-25
申请号：EP12711108.6
申请日：2012-02-15
申请人： Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i. , Fyziologicky Ústav Akademie VED Ceské Republiky, V.V.I.
发明人： CHODOUNSKÁ, Hana , KAPRAS, Vojtech , VYKLICKY, Ladislav , BOROVSKÁ, Jirina , VYKLICKY, Vojtech , VALES , Karel , STUCHLÍK, Ales , RAMBOUSEK, Lukás
CPC分类号： C07J41/0011 , C07J41/0005 , C07J41/005
摘要： Pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, and a method of the production of these compounds and their utilization for treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post traumatic stress disorder, and other diseases related to stress, anxiety, schizophrenia, and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy, and gliomas. The compounds are also used for production of veterinary and human pharmaceutical preparation for treatment of above mentioned diseases and for production of pharmaceutical preparations containing these compounds.
摘要翻译： 孕衍生物，substituiertem与阳离子基团3α-位中，通式I，和生产合成化合物的方法及其在治疗与谷氨酸能神经递质系统，颜色的不平衡神经精神障碍的利用：例如CNS的缺血性损伤 ，神经退行性变化和中枢神经系统的障碍，情感障碍，抑郁症，创伤后应激障碍，以及与应激，焦虑症，精神分裂症，和精神障碍，疼痛，成瘾，多发性硬化，癫痫，神经胶质瘤和其他疾病。 因此，该化合物用于制造用于治疗上述疾病的兽医和人类药物制剂和生产含有合成化合物的药物制剂。
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