Invention Publication
EP2679684A1 Methods and organisms for the growth-coupled production of 1,4-butanediol
审中-公开
生长偶联生产1,4-丁二醇的方法和生物体
- Patent Title: Methods and organisms for the growth-coupled production of 1,4-butanediol
- Patent Title (中): 生长偶联生产1,4-丁二醇的方法和生物体
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Application No.: EP13001195.0Application Date: 2008-08-06
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Publication No.: EP2679684A1Publication Date: 2014-01-01
- Inventor: Burgard, Anthony P. , Van Dien, Stephen J. , Burk, Mark J.
- Applicant: Genomatica, Inc.
- Applicant Address: 10520 Wateridge Circle San Diego, CA 92121 US
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: 10520 Wateridge Circle San Diego, CA 92121 US
- Agency: HOFFMANN EITLE
- Priority: US891602 20070810
- Main IPC: C12N15/52
- IPC: C12N15/52 ; C12P7/18 ; C12N1/00 ; C12N9/04
Abstract:
The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.
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