发明授权
EP2692859B1 METHOD FOR PRODUCING CARDIOMYOCYTE SHEET FROM EMBRYONIC STEM CELLS
有权
一种用于生产KARDIOMYOZYTENFOLIE胚胎干细胞
- 专利标题： METHOD FOR PRODUCING CARDIOMYOCYTE SHEET FROM EMBRYONIC STEM CELLS
- 专利标题（中）： 一种用于生产KARDIOMYOZYTENFOLIE胚胎干细胞
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申请号： EP12763936.7申请日： 2012-03-30
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公开(公告)号： EP2692859B1公开(公告)日： 2016-12-28
- 发明人: OKANO, Teruo , SHIMIZU, Tatsuya , YAMASHITA, Jun , MASUMOTO, Hidetoshi
- 申请人： Tokyo Women's Medical University , Kyoto University
- 申请人地址： 8-1 Kawada-cho Shinjuku-ku Tokyo 162-8666 JP
- 专利权人： Tokyo Women's Medical University,Kyoto University
- 当前专利权人： Tokyo Women's Medical University,Kyoto University
- 当前专利权人地址： 8-1 Kawada-cho Shinjuku-ku Tokyo 162-8666 JP
- 代理机构： D Young & Co LLP
- 优先权： JP2011076235 20110330
- 国际公布： WO2012133945 20121004
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; A61K35/12 ; A61L27/00 ; A61P9/00 ; A61P43/00 ; C12N1/00 ; C12N5/0735 ; C12N15/09 ; A61L27/38 ; A61L27/54 ; A61K35/34 ; A61K35/44
摘要：
The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
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