公开(公告)号：EP2692859B1

公开(公告)日：2016-12-28

申请号：EP12763936.7

申请日：2012-03-30

申请人： Tokyo Women's Medical University ,  Kyoto University

发明人： OKANO, Teruo ,  SHIMIZU, Tatsuya ,  YAMASHITA, Jun ,  MASUMOTO, Hidetoshi

IPC分类号： C12N5/071 ,  A61K35/12 ,  A61L27/00 ,  A61P9/00 ,  A61P43/00 ,  C12N1/00 ,  C12N5/0735 ,  C12N15/09 ,  A61L27/38 ,  A61L27/54 ,  A61K35/34 ,  A61K35/44

CPC分类号： A61K35/34 ,  A61K9/70 ,  A61K35/44 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/20 ,  C12N5/0657 ,  C12N5/0697 ,  C12N2501/01 ,  C12N2501/04 ,  C12N2501/165 ,  C12N2502/1329 ,  C12N2502/1347 ,  C12N2502/28 ,  C12N2506/02 ,  A61K2300/00

摘要： The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.

公开(公告)号：EP2692859A1

公开(公告)日：2014-02-05

申请号：EP12763936.7

申请日：2012-03-30

申请人： Tokyo Women's Medical University ,  Kyoto University

发明人： OKANO, Teruo ,  SHIMIZU, Tatsuya ,  YAMASHITA, Jun ,  MASUMOTO, Hidetoshi

IPC分类号： C12N5/071 ,  A61K35/12 ,  A61L27/00 ,  A61P9/00 ,  A61P43/00 ,  C12N1/00 ,  C12N5/0735 ,  C12N15/09

CPC分类号： A61K35/34 ,  A61K9/70 ,  A61K35/44 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/20 ,  C12N5/0657 ,  C12N5/0697 ,  C12N2501/01 ,  C12N2501/04 ,  C12N2501/165 ,  C12N2502/1329 ,  C12N2502/1347 ,  C12N2502/28 ,  C12N2506/02 ,  A61K2300/00

摘要： The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.

摘要翻译： 本发明提供使用源自胚胎干细胞的一组细胞产生心肌片的方法。 该方法的特征在于混合来自胚胎干细胞的Flk / KDR阳性细胞，心肌细胞，内皮细胞和壁细胞，并培养混合细胞。 此外，心肌片可以用作心脏病的治疗剂，因为VEGF从片材中释放出来。