发明公开
- 专利标题: FUSION PROTEIN
- 专利标题(中): 融合蛋白
-
申请号: EP12770896.4申请日: 2012-04-02
-
公开(公告)号: EP2698386A1公开(公告)日: 2014-02-19
- 发明人: KOGURE, Takahisa , NAKAJIMA, Kenji , HOMMA, Masayuki
- 申请人: Nihon Pharmaceutical Co., Ltd.
- 申请人地址: 9-8 Higashikanda 1-chome Chiyoda-ku Tokyo 101-0031 JP
- 专利权人: Nihon Pharmaceutical Co., Ltd.
- 当前专利权人: Nihon Pharmaceutical Co., Ltd.
- 当前专利权人地址: 9-8 Higashikanda 1-chome Chiyoda-ku Tokyo 101-0031 JP
- 代理机构: Patentanwälte Ruff, Wilhelm, Beier, Dauster & Partner
- 优先权: JP2011088762 20110413
- 国际公布: WO2012141026 20121018
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; A61K38/00 ; A61P37/06 ; C07K14/47 ; C07K16/18 ; C12P21/02 ; C12N15/09
摘要:
The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production.
A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
公开/授权文献
- EP2698386B8 FUSION PROTEIN 公开/授权日:2018-02-07
信息查询