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公开(公告)号：EP2698386A1
公开(公告)日：2014-02-19
申请号：EP12770896.4
申请日：2012-04-02
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production.
A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.摘要翻译： 本发明提供了一种能特异性抑制自身抗体的新型融合蛋白，能够有效预防或治疗自身抗体型自身免疫性疾病，并且其表达量足以用于工业生产。 1。一种融合蛋白，其特征在于，含有被自身抗体型自身免疫病的原因的自身抗体识别的位点的蛋白质（X）与含有抗体重链恒定区片段的蛋白质（A）连接， 使用由一个或多个氨基酸组成的接头肽（L）的抗体依赖性细胞毒性，其中蛋白质（X），接头肽（L）和蛋白质（A）以此顺序通过手段连接 肽键从N末端到C末端。
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公开(公告)号：EP2698386B1
公开(公告)日：2017-12-20
申请号：EP12770896.4
申请日：2012-04-02
IPC分类号： C07K19/00 , A61K38/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12P21/02 , C12N15/09 , C07K14/705
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production. A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
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公开(公告)号：EP2698386B8
公开(公告)日：2018-02-07
申请号：EP12770896.4
申请日：2012-04-02
IPC分类号： C07K19/00 , A61K38/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12P21/02 , C12N15/09 , C07K14/705
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production. A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
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