发明公开
EP2701725A1 CHEMICAL MODIFICATION OF APOLIPOPROTEIN MIMETIC PEPTIDES FOR THE PRODUCTION OF THERAPEUTIC AGENTS
审中-公开
TABLES的化学修饰的MIME APOLIPOPROTEINPEPTIDEN药品生产
- 专利标题： CHEMICAL MODIFICATION OF APOLIPOPROTEIN MIMETIC PEPTIDES FOR THE PRODUCTION OF THERAPEUTIC AGENTS
- 专利标题（中）： TABLES的化学修饰的MIME APOLIPOPROTEINPEPTIDEN药品生产
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申请号： EP12726266.5申请日： 2012-04-30
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公开(公告)号： EP2701725A1公开(公告)日： 2014-03-05
- 发明人: REMALEY, Alan, T. , AMAR, Marcelo , SVIRIDOV, Denis , IKPOT, Imoh, Z. , OSEI-HWEDIEH, David , TURNER, Scott
- 申请人： Kinemed, Inc. , United States Department of Health and Human Services
- 申请人地址： 5980 Horton Street, Suite 470 Emeryville, CA 94608 US
- 专利权人： Kinemed, Inc.,United States Department of Health and Human Services
- 当前专利权人： Kinemed, Inc.,United States Department of Health and Human Services
- 当前专利权人地址： 5980 Horton Street, Suite 470 Emeryville, CA 94608 US
- 代理机构： Harrison Goddard Foote LLP
- 优先权： US201161480986P 20110429
- 国际公布： WO2012149563 20121101
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/775
摘要：
Hydrocarbon stapling of apolipoprotein mimetic peptides increases the helicity of the peptides, enhances their ability to promote cholesterol efflux by multiple mechanisms and makes them resistant to proteolysis. Hydrocarbon stapled amphipathic helical peptides are useful in the treatment of cardiovascular diseases and other disorders.
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