专利检索 ap:"United States Department of Health AND Human Services" 第 1 页

1.

发明授权
SUPERAGONISTS, PARTIAL AGONISTS AND ANTAGONISTS OF INTERLEUKIN-2 有权

公开(公告)号：EP3134102B1

公开(公告)日：2019-07-03

申请号：EP15782644.7

申请日：2015-04-24

申请人： The Board of Trustees of The Leland Stanford Junior University , United States Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

发明人： GARCIA, K., Christopher , MITRA, Suman , LEONARD, Warren, J. , RING, Aaron, M.

IPC分类号： A61K38/00 , A61K38/20 , C07K14/55

2.

发明公开
METHODS AND COMPOSITIONS OF MMA CONSTRUCTS AND VECTORS 审中-公开

公开(公告)号：EP3823676A1

公开(公告)日：2021-05-26

申请号：EP19749899.1

申请日：2019-07-16

申请人： Selecta Biosciences, Inc. , National Institutes of Health, a Component of the United States Department of Health and Human Services

发明人： KELLER, Peter , KISHIMOTO, Takashi Kei , VENDITTI, Charles P. , CHANDLER, Randy J.

IPC分类号： A61K48/00 , C12N15/86 , C12N15/864

3.

发明公开
CHEMICAL MODIFICATION OF APOLIPOPROTEIN MIMETIC PEPTIDES FOR THE PRODUCTION OF THERAPEUTIC AGENTS 审中-公开
标题翻译： TABLES的化学修饰的MIME APOLIPOPROTEINPEPTIDEN药品生产

公开(公告)号：EP2701725A1

公开(公告)日：2014-03-05

申请号：EP12726266.5

申请日：2012-04-30

申请人： Kinemed, Inc. , United States Department of Health and Human Services

发明人： REMALEY, Alan, T. , AMAR, Marcelo , SVIRIDOV, Denis , IKPOT, Imoh, Z. , OSEI-HWEDIEH, David , TURNER, Scott

IPC分类号： A61K38/17 , C07K14/775

CPC分类号： C07K14/775 , A61K38/00

摘要： Hydrocarbon stapling of apolipoprotein mimetic peptides increases the helicity of the peptides, enhances their ability to promote cholesterol efflux by multiple mechanisms and makes them resistant to proteolysis. Hydrocarbon stapled amphipathic helical peptides are useful in the treatment of cardiovascular diseases and other disorders.

4.

发明公开
COMPOUNDS FOR IMPROVING MRNA SPLICING 审中-公开
标题翻译：用于改善MRNA拼接的化合物

公开(公告)号：EP3244891A1

公开(公告)日：2017-11-22

申请号：EP16737944.5

申请日：2016-01-15

申请人： The General Hospital Corporation , United States Department of Health and Human Services

发明人： SLAUGENHAUPT, Susan, A. , JOHNSON, Graham , PAQUETTE, William, D. , ZHANG, Wei , MARUGAN, Juan

IPC分类号： A61K31/4196 , A61P25/28 , C07D251/00 , C07D339/06

CPC分类号： C07D473/34 , A61P25/28 , C07D405/12 , C07D417/12 , C07D471/04 , C07D473/16 , C07D487/04 , C07D495/04 , C07D513/04

摘要： Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.