发明公开
EP2707718A1 METHOD OF IDENTIFYING COMPOUNDS THAT SPECIFICALLY MODULATE THE INTERACTION OF FGFR1 AND BETA-KLOTHO
审中-公开
方法FGFR1和BETA KLOTHO的相互作用中识别化合物作为特异性调节
- 专利标题： METHOD OF IDENTIFYING COMPOUNDS THAT SPECIFICALLY MODULATE THE INTERACTION OF FGFR1 AND BETA-KLOTHO
- 专利标题（中）： 方法FGFR1和BETA KLOTHO的相互作用中识别化合物作为特异性调节
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申请号： EP12706412.9申请日： 2012-02-20
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公开(公告)号： EP2707718A1公开(公告)日： 2014-03-19
- 发明人: LI, Yang , WU, Xinle , GE, Hongfei , BARIBAULT, Helene , LEMON, Bryan , SHENG, Jackie Zeqi , VONDERFECHT, Steven , WEISZMANN, Jennifer Veronica , GARDNER, Jonitha , LEE, Ki Jeong
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US201161484585P 20110510
- 国际公布： WO2012154263 20121115
- 主分类号： G01N33/566
- IPC分类号： G01N33/566 ; G01N33/74 ; G01N33/50
摘要：
Methods of identifying compounds that specifically modulate the interaction of FGFR1 and β-Klotho are disclosed. Identified compounds can be useful in treating metabolic diseases and disorders that involve the interaction of FGFR1 and β-Klotho. In various embodiments the metabolic disease or disorder is diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
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