公开(公告)号：EP2707718A1

公开(公告)日：2014-03-19

申请号：EP12706412.9

申请日：2012-02-20

申请人： Amgen Inc.

发明人： LI, Yang ,  WU, Xinle ,  GE, Hongfei ,  BARIBAULT, Helene ,  LEMON, Bryan ,  SHENG, Jackie Zeqi ,  VONDERFECHT, Steven ,  WEISZMANN, Jennifer Veronica ,  GARDNER, Jonitha ,  LEE, Ki Jeong

IPC分类号： G01N33/566 ,  G01N33/74 ,  G01N33/50

CPC分类号： G01N33/74 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5067 ,  G01N2333/50 ,  G01N2500/02

摘要： Methods of identifying compounds that specifically modulate the interaction of FGFR1 and β-Klotho are disclosed. Identified compounds can be useful in treating metabolic diseases and disorders that involve the interaction of FGFR1 and β-Klotho. In various embodiments the metabolic disease or disorder is diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.