发明公开
- 专利标题： ARYLOXYMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS
- 专利标题（中）： 作为PDE10抑制剂的芳氧基甲基环丙烷衍生物
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申请号： EP12789446.7申请日： 2012-05-21
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公开(公告)号： EP2714041A1公开(公告)日： 2014-04-09
- 发明人: BRESLIN, Michael J. , COX, Christopher D. , HARTINGH, Timothy J. , PERO, Joseph , RAHEEM, Izzat T. , ROSSI, Michael , VASSALLO, Laura
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US201161489457P 20110524
- 国际公布： WO2012162213 20121129
- 主分类号： A61K31/444
- IPC分类号： A61K31/444
摘要：
The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
公开/授权文献
- EP2714041B1 ARYLOXYMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS 公开/授权日：2016-10-19
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