A blood circuit assembly engagement device for a dialysis unit, comprising: an actuator movably mounted to a panel of the dialysis unit adjacent a plurality of control ports, the actuator movable between a retention position and an ejection position; a retainer element coupled to the actuator and arranged, with the actuator in the retention position, to retain a blood circuit assembly mounted to the panel of the dialysis unit on the panel, and arranged, with the actuator in the ejection position, to release the blood circuit assembly for removal from the panel of the dialysis unit; and an ejector element coupled to the actuator and arranged, with the actuator moved from the retention position to the ejection position, to urge the blood circuit assembly away from the panel.