- 专利标题： NEPRILYSIN INHIBITORS
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申请号： EP12724047.1申请日： 2012-05-18
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公开(公告)号： EP2714660B1公开(公告)日： 2018-09-26
- 发明人: FLEURY, Melissa , GENDRON, Roland , HUGHES, Adam, D. , SCHMIDT, Jane
- 申请人： Theravance Biopharma R&D IP, LLC
- 申请人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人： Theravance Biopharma R&D IP, LLC
- 当前专利权人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Abel & Imray
- 优先权： US201161491749P 20110531
- 国际公布： WO2012166390 20121206
- 主分类号： C07D213/81
- IPC分类号： C07D213/81 ; C07D239/28 ; C07D249/10 ; C07D261/18 ; C07D401/06 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; A61K31/4418 ; A61P9/12
摘要：
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- EP2714660A1 NEPRILYSIN INHIBITORS 公开/授权日：2014-04-09
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