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公开(公告)号：EP2714660B1
公开(公告)日：2018-09-26
申请号：EP12724047.1
申请日：2012-05-18
IPC分类号： C07D213/81 , C07D239/28 , C07D249/10 , C07D261/18 , C07D401/06 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/4418 , A61P9/12
CPC分类号： C07D261/18 , A01N47/16 , A61K31/4196 , A61K31/42 , A61K31/4355 , A61K31/437 , A61K45/06 , A61K47/55 , A61K47/6895 , C07D213/81 , C07D237/04 , C07D237/24 , C07D239/28 , C07D241/24 , C07D249/04 , C07D249/10 , C07D249/18 , C07D263/34 , C07D307/68 , C07D333/38 , C07D401/06 , C07D471/04 , C07D487/04 , C07D498/04 , C09K15/30
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：EP4061809A1
公开(公告)日：2022-09-28
申请号：EP20825407.8
申请日：2020-11-20
发明人： OWENS, Christina , KULYK, Svitlana , SULLIVAN, Steven, D., E. , ALLEGRETTI, Paul , LOO, Mandy , KOZAK, Jennifer , ZHAO, Chen , FENSTER, Erik , HUGHES, Adam, D.
IPC分类号： C07D401/14 , C07D471/04 , A61P11/00 , A61K31/4375
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公开(公告)号：EP2714648B1
公开(公告)日：2017-08-16
申请号：EP12724046.3
申请日：2012-05-18
IPC分类号： C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/22 , C07D231/26 , C07D333/38 , C07D233/61 , C07C231/02 , C07D257/04 , C07C233/87 , C07D207/327 , C07D495/02 , C07D207/333 , C07D295/155 , C07D213/56
CPC分类号： C07D231/26 , C07C231/02 , C07C233/87 , C07D207/327 , C07D207/333 , C07D213/56 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/22 , C07D233/61 , C07D257/04 , C07D295/155 , C07D333/38 , C07D495/02
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