发明公开
- 专利标题： CYCLIC AMIDE DERIVATIVE
- 专利标题（中）： 环酰胺衍生物
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申请号： EP12777792.8申请日： 2012-04-11
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公开(公告)号： EP2716636A1公开(公告)日： 2014-04-09
- 发明人: OKANO, Akihiro , OHKOUCHI, Munetaka , MAKABE, Muneyoshi
- 申请人： Mochida Pharmaceutical Co., Ltd.
- 申请人地址： 7 Yotsuya 1-chome Shinjuku-ku Tokyo 160-8515 JP
- 专利权人： Mochida Pharmaceutical Co., Ltd.
- 当前专利权人： Mochida Pharmaceutical Co., Ltd.
- 当前专利权人地址： 7 Yotsuya 1-chome Shinjuku-ku Tokyo 160-8515 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2011102535 20110428; JP2011185340 20110826; PCT/JP2011/073355 20111011; JP2012044857 20120229
- 国际公布： WO2012147516 20121101
- 主分类号： C07D275/02
- IPC分类号： C07D275/02 ; A61K31/4155 ; A61K31/425 ; A61K31/433 ; A61K31/4439 ; A61K31/54 ; A61K31/541 ; A61K31/549 ; A61P3/04 ; A61P3/10 ; A61P43/00 ; C07D279/02 ; C07D285/10 ; C07D285/16 ; C07D417/12 ; C07D417/14
摘要：
[Problem]
To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or the like.
[Means of solving the problem]
A compound of Formula (III):
(where f is 0 to 2; g is 1 to 4; j is 0 to 3; k is 0 to 2; n is 0 to 2; p is 0 to 4; h is 0 to 3; q1 id 0 to 3; q2 is 0 or 1; r1 is 0 to 2 (with the proviso that q1+q2+r1 is 0 to 5); J 1a is -CR 11a -, N; J 2 is -CR 12a R 12b -, -CR 12c -; T is -CH 2 -, O, -S(O) i - (i is an integer of 0 to 2) or -NR 7 -; X is O, S, or -NR 7 -; ring A"' is a benzene ring, a pyridine ring; ring B' is a benzene ring, a pyridine ring, a pyrimidine ring; and R 1 to R 14 are specific groups),
a salt of the compound, or a solvate of the salt or the compound.
To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or the like.
[Means of solving the problem]
A compound of Formula (III):
(where f is 0 to 2; g is 1 to 4; j is 0 to 3; k is 0 to 2; n is 0 to 2; p is 0 to 4; h is 0 to 3; q1 id 0 to 3; q2 is 0 or 1; r1 is 0 to 2 (with the proviso that q1+q2+r1 is 0 to 5); J 1a is -CR 11a -, N; J 2 is -CR 12a R 12b -, -CR 12c -; T is -CH 2 -, O, -S(O) i - (i is an integer of 0 to 2) or -NR 7 -; X is O, S, or -NR 7 -; ring A"' is a benzene ring, a pyridine ring; ring B' is a benzene ring, a pyridine ring, a pyrimidine ring; and R 1 to R 14 are specific groups),
a salt of the compound, or a solvate of the salt or the compound.
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