A mixer machine for mixing at least one substance in powder with at least one liquid comprises a mixing chamber 10, a turbine 40 placed in said chamber and susceptible to be placed in rotation in such a way as to generate a downward flow of the substance in powder along the inner surface of the side wall 12 of said mixing chamber, and dis¬ penser means of the liquid 50 suitable to generate at least one pres¬ surised jet of liquid nebulised directly against said inner surface, so as to cause an interaction between the particles of the substance in pow¬ der and the particles of the nebulised liquid having the effect of an in¬ stantaneous mixing of said substance with said liquid.