发明公开
- 专利标题： BIOCHEMICAL MARKERS FOR NEURODEGENERATIVE CONDITIONS
- 专利标题（中）： 生物化学标记物FÜR神经干细胞ERKRANKUNGEN
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申请号： EP12733674.1申请日： 2012-07-04
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公开(公告)号： EP2729578A1公开(公告)日： 2014-05-14
- 发明人: BARASCUK, Natascha , KARSDAL, Morten , HENRIKSEN, Kim
- 申请人： Nordic Bioscience A/S
- 申请人地址： Herlev Hovedgade 207 2730 Herlev DK
- 专利权人： Nordic Bioscience A/S
- 当前专利权人： Nordic Bioscience A/S
- 当前专利权人地址： Herlev Hovedgade 207 2730 Herlev DK
- 代理机构： Beck Greener
- 优先权： GB201111361 20110704
- 国际公布： WO2013004717 20130110
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; G01N33/68 ; C07K14/47 ; C07K16/00 ; C12N5/00
摘要：
Provided herein is a method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions. The method comprises cleaving a Tau protein by a secretase, such as ADAM10, to form a neo-epitope. The method comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of the antibody to peptide fragments comprising the neo-epitope in the sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
公开/授权文献
- EP2729578B1 BIOCHEMICAL MARKERS FOR NEURODEGENERATIVE CONDITIONS 公开/授权日：2020-03-11
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