公开(公告)号：EP4430399A1

公开(公告)日：2024-09-18

申请号：EP22814367.3

申请日：2022-11-08

申请人： Nordic Bioscience A/S

发明人： WILLUMSEN, Nicholas ,  BAY-JENSEN, Anne-Christine ,  KARSDAL, Morten

IPC分类号： G01N33/574 ,  G01N33/68

CPC分类号： G01N33/6854 ,  G01N2800/5220130101 ,  G01N33/57488 ,  G01N33/566 ,  G01N33/6887 ,  G01N2333/7820130101

公开(公告)号：EP3596120B1

公开(公告)日：2023-12-13

申请号：EP18713147.9

申请日：2018-03-14

发明人： MANON-JENSEN, Tina ,  KARSDAL, Morten

IPC分类号： C07K16/18

公开(公告)号：EP3512877A1

公开(公告)日：2019-07-24

申请号：EP17772626.2

申请日：2017-09-13

申请人： Nordic Bioscience A/S

发明人： WILLUMSEN, Nicholas ,  BAGER, Cecilie, Liv ,  BAY JENSEN, Anne-Cecilie ,  QUILEZ-ALVAREZ, Antonio ,  KARSDAL, Morten ,  ORSNES-LEEMING, Diana ,  MANON-JENSEN, Tina

IPC分类号： C07K14/78 ,  C12Q1/37 ,  G01N33/574

公开(公告)号：EP2731960B1

公开(公告)日：2016-11-16

申请号：EP12731501.8

申请日：2012-07-06

申请人： Nordic Bioscience A/S

发明人： LEEMING, Diana Julie ,  KARSDAL, Morten ,  VASSILIADIS, Efstathios

IPC分类号： C07K7/06 ,  C07K16/18 ,  G01N33/68

CPC分类号： G01N33/6887 ,  C07K14/4716 ,  C07K16/18 ,  C07K2317/34 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/4712 ,  G01N2800/32

公开(公告)号：EP2353007B1

公开(公告)日：2016-01-27

申请号：EP09764213.6

申请日：2009-11-11

申请人： Nordic Bioscience A/S

发明人： LEEMING, Diana Julie ,  BYRJALSEN, Inger ,  QVIST, Per ,  KARSDAL, Morten Asser

IPC分类号： G01N33/564

CPC分类号： G01N33/6887 ,  G01N2800/105

公开(公告)号：EP2414844B1

公开(公告)日：2014-12-10

申请号：EP10715752.1

申请日：2010-03-29

申请人： Nordic Bioscience A/S ,  Novartis AG

发明人： VEIDAL, Sanne S. ,  KARSDAL, Morten A. ,  LEEMING, Diana J. ,  BARASCUK, Natasha ,  SKJOT-ARKIL, Helene ,  SEGOVIA-SILVESTRE, Antonio ,  VASSILIADIS, Efstathios

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/37 ,  G01N2333/4737 ,  G01N2333/78 ,  G01N2800/085 ,  G01N2800/32 ,  G01N2800/50

摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.

公开(公告)号：EP2538222A3

公开(公告)日：2013-04-24

申请号：EP12185053.1

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C07K14/47 ,  C12Q1/37 ,  G01N33/542

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is CRP and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过蛋白酶切割动脉粥样硬化斑块的蛋白质而形成的新表位的肽片段的生物测定法，其中所述蛋白质是CRP并且所述方法包括使样品如尿液或血清与抗体反应 与新表位结合，并测定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定可预测心血管疾病事件的风险。

公开(公告)号：EP2538223A8

公开(公告)日：2013-02-27

申请号：EP12185057.2

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is decorin and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

公开(公告)号：EP2538218A8

公开(公告)日：2013-02-27

申请号：EP12185056.4

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/542 ,  C12Q1/37 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque, wherein the protein is biglycan and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过切割动脉粥样硬化斑块的蛋白质形成的新表位的肽片段的生物测定法，其中所述蛋白质是双糖链蛋白聚糖，并且所述方法包括使样品例如尿液或血清与可与新霉素反应的抗体 并确定所述免疫结合配偶体与所述样品中的肽片段的结合水平。 该测定可预测心血管疾病事件的风险。

公开(公告)号：EP1651249B1

公开(公告)日：2012-09-12

申请号：EP04741224.2

申请日：2004-07-22

申请人： Novartis AG ,  Novartis Pharma GmbH ,  Nordic Bioscience A/S

发明人： AZRIA, Moise ,  CHRISTIANSEN, Claus ,  BATEMAN, Simon, David ,  LI, Shoufeng

IPC分类号： A61K38/23 ,  A61K9/20 ,  A61K47/16 ,  A61P19/08

CPC分类号： A61K38/23 ,  A61K9/0031 ,  A61K9/0043 ,  A61K9/2013 ,  A61K9/2054 ,  A61K45/06 ,  A61K47/16 ,  A61K47/183 ,  A61K47/48169 ,  A61K47/56