发明公开
- 专利标题: NO- AND H2S- RELEASING COMPOUNDS
- 专利标题(中): NO-和H2S释放化合物
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申请号: EP12824542.0申请日: 2012-08-15
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公开(公告)号: EP2744487A2公开(公告)日: 2014-06-25
- 发明人: KASHFI, Khosrow , KODELA, Ravinder
- 申请人: Research Foundation Of The City University Of New York
- 申请人地址: 230 West 41st Street New York, NY 10036 US
- 专利权人: Research Foundation Of The City University Of New York
- 当前专利权人: Research Foundation Of The City University Of New York
- 当前专利权人地址: 230 West 41st Street New York, NY 10036 US
- 代理机构: Jansen, Cornelis Marinus
- 优先权: US201161523513P 20110815; US201261615700P 20120326; US201261635624P 20120419
- 国际公布: WO2013025790 20130221
- 主分类号: A61K31/13
- IPC分类号: A61K31/13 ; A01N33/24
摘要:
This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
公开/授权文献
- EP2744487B1 NO- AND H2S- RELEASING COMPOUNDS 公开/授权日:2016-10-05
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