发明公开
EP2753607A1 BICYCLO[6.1.0]NON-4-YNE REAGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES
有权
双环[6.1.0]壬-4-炔试剂FOR CHEMICAL＆XA; 寡核苷酸修改
- 专利标题： BICYCLO[6.1.0]NON-4-YNE REAGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES
- 专利标题（中）： 双环[6.1.0]壬-4-炔试剂FOR CHEMICAL＆XA; 寡核苷酸修改
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申请号： EP12768941.2申请日： 2012-09-07
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公开(公告)号： EP2753607A1公开(公告)日： 2014-07-16
- 发明人: HODGES, John, Cooke , VAN DELFT, Floris, Louis , VAN BERKEL, Sander, Sebastiaan , VERKADE, Jorge , BERRY, David, A.
- 申请人： Hodges, John Cooke , Berry, Lana L. , Van Delft, Floris Louis , Van Berkel, Sander Sebastiaan , Verkade, Jorge
- 申请人地址： 4307 Walden Drive Ann Arbor, MI 48105 US
- 专利权人： Hodges, John Cooke,Berry, Lana L.,Van Delft, Floris Louis,Van Berkel, Sander Sebastiaan,Verkade, Jorge
- 当前专利权人： Hodges, John Cooke,Berry, Lana L.,Van Delft, Floris Louis,Van Berkel, Sander Sebastiaan,Verkade, Jorge
- 当前专利权人地址： 4307 Walden Drive Ann Arbor, MI 48105 US
- 代理机构： Duncan, Garreth Andrew
- 优先权： US201161532867P 20110909; US201261613599P 20120321
- 国际公布： WO2013036748 20130314
- 主分类号： C07D239/22
- IPC分类号： C07D239/22 ; C07F9/02 ; G01N33/531 ; G01N33/68
摘要：
The present invention provides for compounds of Formulae I and II: wherein
1 R,
2 R, L, X, q, Z, A, and B have any of the values disclosed in the specification. Compounds of Formulae I and II are useful as reagents to introduce bicyclo[6.1.0]non-4- yne groups into oligonucleotide chains to serve as points of attachment for chemical tags.
1 R,
2 R, L, X, q, Z, A, and B have any of the values disclosed in the specification. Compounds of Formulae I and II are useful as reagents to introduce bicyclo[6.1.0]non-4- yne groups into oligonucleotide chains to serve as points of attachment for chemical tags.
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