专利检索 ap:"Hodges, John Cooke" 第 1 页

1.

发明公开
BICYCLO[6.1.0]NON-4-YNE REAGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES 有权
标题翻译：双环[6.1.0]壬-4-炔试剂FOR CHEMICAL＆XA; 寡核苷酸修改

公开(公告)号：EP2753607A1

公开(公告)日：2014-07-16

申请号：EP12768941.2

申请日：2012-09-07

申请人： Hodges, John Cooke , Berry, Lana L. , Van Delft, Floris Louis , Van Berkel, Sander Sebastiaan , Verkade, Jorge

发明人： HODGES, John, Cooke , VAN DELFT, Floris, Louis , VAN BERKEL, Sander, Sebastiaan , VERKADE, Jorge , BERRY, David, A.

IPC分类号： C07D239/22 , C07F9/02 , G01N33/531 , G01N33/68

CPC分类号： C07D239/22 , C07F9/2408 , C07F9/65586

摘要： The present invention provides for compounds of Formulae I and II: wherein
1 R,
2 R, L, X, q, Z, A, and B have any of the values disclosed in the specification. Compounds of Formulae I and II are useful as reagents to introduce bicyclo[6.1.0]non-4- yne groups into oligonucleotide chains to serve as points of attachment for chemical tags.