发明公开
EP2758379A1 MORPHOLINO SUBSTITUTED UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS
有权
2-吗啉代-1,3,5-三嗪的尿素和氨基甲酸酯衍生物作为mTOR抑制剂用于免疫学或增殖性疾病的治疗
- 专利标题： MORPHOLINO SUBSTITUTED UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS
- 专利标题（中）： 2-吗啉代-1,3,5-三嗪的尿素和氨基甲酸酯衍生物作为mTOR抑制剂用于免疫学或增殖性疾病的治疗
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申请号： EP12761738.9申请日： 2012-09-21
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公开(公告)号： EP2758379A1公开(公告)日： 2014-07-30
- 发明人: LYNCH, Rosemary , CANSFIELD, Andrew David , HARDY, Daniel Paul , SUNOSE, Mihiro , MOREL, Adeline , CONVERY, Laura , ADREGO, Rita
- 申请人： Cellzome Limited
- 申请人地址： 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 专利权人： Cellzome Limited
- 当前专利权人： Cellzome Limited
- 当前专利权人地址： 980 Great West Road Brentford, Middlesex TW8 9GS GB
- 代理机构： Shore, Andrew David
- 优先权： EP11182221 20110921
- 国际公布： WO2013041652 20130328
- 主分类号： C07D251/22
- IPC分类号： C07D251/22 ; C07D401/12 ; C07D407/12 ; C07D413/04 ; A61K31/53 ; A61P37/02 ; A61P37/04 ; A61P37/06 ; A61P37/08 ; A61P35/00
摘要：
The invention relates to compounds of formula (I), wherein m, n, R
1 , T
0 and T
1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.
1 , T
0 and T
1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.
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