发明公开
EP2760465A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE RETINAL CONDITIONS
审中-公开
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VEN DEGENERATIVEN NETZHAUTERKRANKUNGEN
- 专利标题： COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE RETINAL CONDITIONS
- 专利标题（中）： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VEN DEGENERATIVEN NETZHAUTERKRANKUNGEN
-
申请号： EP12772743.6申请日： 2012-10-01
-
公开(公告)号： EP2760465A1公开(公告)日： 2014-08-06
- 发明人: CAMPBELL, Matthew , HUMPHRIES, Peter , HUMPHRIES, Marian , KIANG, Anna-Sophia , DOYLE, Sarah , O'NEILL, Luke
- 申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 申请人地址： College Green Dublin 2 IE
- 专利权人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 当前专利权人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 当前专利权人地址： College Green Dublin 2 IE
- 代理机构： Hally, Anna-Louise
- 优先权： GB201116815 20110929; GB201205131 20120323
- 国际公布： WO2013045694 20130404
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61P27/02
摘要：
The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.
公开/授权文献
信息查询
IPC分类:
