发明公开
EP2768834A1 SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
有权
取代的双环氮杂环丙烷类化合物及其类似物作为沙丁胺醇调节剂
- 专利标题： SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
- 专利标题（中）： 取代的双环氮杂环丙烷类化合物及其类似物作为沙丁胺醇调节剂
-
申请号： EP12842012.2申请日： 2012-10-19
-
公开(公告)号： EP2768834A1公开(公告)日： 2014-08-27
- 发明人: BLUM, Charles, A. , SPRINGER, Stephanie, K. , VU, Chi, B.
- 申请人： GlaxoSmithKline LLC
- 申请人地址： Corporation Service Company 2711 Centerville Road, Suite 400 Wilmington DE 19808 US
- 专利权人： GlaxoSmithKline LLC
- 当前专利权人： GlaxoSmithKline LLC
- 当前专利权人地址： Corporation Service Company 2711 Centerville Road, Suite 400 Wilmington DE 19808 US
- 代理机构： Valentine, Jill Barbara
- 优先权： US201161549736P 20111020
- 国际公布： WO2013059589 20130425
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided, are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
公开/授权文献
信息查询
