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    SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
    9.
    发明公开
    SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS 有权
    取代的双环氮杂环丙烷类化合物及其类似物作为沙丁胺醇调节剂

    公开(公告)号：EP2768834A1

    公开(公告)日：2014-08-27

    申请号：EP12842012.2

    申请日：2012-10-19

    申请人： GlaxoSmithKline LLC

    发明人： BLUM, Charles, A. ,  SPRINGER, Stephanie, K. ,  VU, Chi, B.

    IPC分类号： C07D487/04

    CPC分类号： A61K31/5377 ,  A61K31/5025 ,  C07D487/04

    摘要： Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided, are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

    摘要翻译： 本文提供了新颖的取代的双环氮杂杂环沉默调节蛋白调节化合物及其使用方法。 瑟土因调节性化合物可用于增加细胞寿命，以及治疗和/或预防各种疾病和病症，包括例如与衰老或压力相关的疾病或病症，糖尿病，肥胖症，神经退行性疾病， 心血管疾病，凝血障碍，炎症，癌症和/或潮红以及将受益于线粒体活性增加的疾病或病症。 还提供了包含沉默调节蛋白调节化合物与另一种治疗剂组合的组合物。