发明公开
EP2772481A8 NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
有权
新化合物作为KCNQ钾通道激动剂，其制备方法及其用途
- 专利标题： NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
- 专利标题（中）： 新化合物作为KCNQ钾通道激动剂，其制备方法及其用途
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申请号： EP12843367.9申请日： 2012-10-23
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公开(公告)号： EP2772481A8公开(公告)日： 2014-11-26
- 发明人: NAN, Fajun , LI, Min , GAO, Zhaobing , CHEN, Fei , ZHANG, Yangming , ZHOU, Pingzheng , HU, Haining , XU, Haiyan , LIU, Sheng
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： 555 Zuchongzhi Road Zhangjiang, Pudong Shanghai 201203 CN
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： 555 Zuchongzhi Road Zhangjiang, Pudong Shanghai 201203 CN
- 代理机构： Tischner, Oliver
- 优先权： CN201110328036 20111025
- 国际公布： WO2013060097 20130502
- 主分类号： C07C271/28
- IPC分类号： C07C271/28 ; C07C269/04 ; C07C233/43 ; C07C231/02 ; C07D235/26 ; A61K31/27 ; A61K31/167 ; A61K31/4184 ; A61P25/08 ; A61P25/04 ; A61P25/28 ; A61P25/00 ; A61P9/10
摘要：
The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medcine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.
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