Alkylated piperazine compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for
in vitro ,
in situ , and
in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.