发明公开
- 专利标题: BINDING MOLECULES FOR BCMA AND CD3
- 专利标题(中): 结合分子FOR BCMA和CD3
-
申请号: EP12803509.4申请日: 2012-11-15
-
公开(公告)号: EP2780374A1公开(公告)日: 2014-09-24
- 发明人: KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
- 申请人: Amgen Research (Munich) GmbH , Boehringer Ingelheim International GmbH
- 申请人地址: Staffelseestrasse 2 81477 München DE
- 专利权人: Amgen Research (Munich) GmbH,Boehringer Ingelheim International GmbH
- 当前专利权人: Amgen Research (Munich) GmbH,Boehringer Ingelheim International GmbH
- 当前专利权人地址: Staffelseestrasse 2 81477 München DE
- 代理机构: Schiweck, Weinzierl & Koch
- 优先权: US201161560144P 20111115; US201161560149P 20111115; US201161560162P 20111115; US201161560178P 20111115; US201161560183P 20111115; US201261651474P 20120524; US201261651486P 20120524
- 国际公布: WO2013072415 20130523
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; A61K39/395 ; A61P35/02 ; A61P37/00
摘要:
The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
公开/授权文献
- EP2780374B1 BINDING MOLECULES FOR BCMA AND CD3 公开/授权日:2019-08-21
信息查询