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公开(公告)号：EP2970472A1
公开(公告)日：2016-01-20
申请号：EP14716251.5
申请日：2014-03-14
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
摘要翻译： 本发明涉及包含第一和第二结合结构域的结合分子，其中第一结合结构域能够结合BCMA的表位簇，并且第二结合结构域能够结合T细胞CD3受体复合物。 此外，本发明提供编码结合分子的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的结合分子的方法，所述结合分子的医学用途和包含所述结合分子的试剂盒。
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公开(公告)号：EP2780375A1
公开(公告)日：2014-09-24
申请号：EP12805432.7
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
CPC分类号： C07K16/468 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/70578 , C07K16/2809 , C07K16/2875 , C07K16/2878 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/43
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP2780374A1
公开(公告)日：2014-09-24
申请号：EP12803509.4
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
CPC分类号： C07K16/468 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/70578 , C07K16/2809 , C07K16/2875 , C07K16/2878 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/43
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3611193A1
公开(公告)日：2020-02-19
申请号：EP19196304.0
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP2780374B1
公开(公告)日：2019-08-21
申请号：EP12803509.4
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
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公开(公告)号：EP2780375B1
公开(公告)日：2019-09-11
申请号：EP12805432.7
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
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公开(公告)号：EP3912997A3
公开(公告)日：2021-12-15
申请号：EP21158075.8
申请日：2014-03-14
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3912997A2
公开(公告)日：2021-11-24
申请号：EP21158075.8
申请日：2014-03-14
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00 , A61P35/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3623385A8
公开(公告)日：2020-05-06
申请号：EP19192268.1
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3623385A1
公开(公告)日：2020-03-18
申请号：EP19192268.1
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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