发明公开
EP2788759A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
审中-公开
方法和组合物诊断和预后肾损伤和肾功能衰竭的
- 专利标题： METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
- 专利标题（中）： 方法和组合物诊断和预后肾损伤和肾功能衰竭的
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申请号： EP12854991.2申请日： 2012-12-07
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公开(公告)号： EP2788759A1公开(公告)日： 2014-10-15
- 发明人: ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
- 申请人： Astute Medical, Inc.
- 申请人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
- 专利权人： Astute Medical, Inc.
- 当前专利权人： Astute Medical, Inc.
- 当前专利权人地址： Blg 2 R. 645 3550 General Atomics Court San Diego, CA 92121 US
- 代理机构： Schiweck, Weinzierl & Koch
- 优先权： US201161568447P 20111208; US201261593561P 20120201
- 国际公布： WO2013086359 20130613
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Insulin-like growth factor-binding protein 7, Beta-2-glycoprotein 1, Metalloproteinase inhibitor 2, Alpha-1 Antitrypsin, Leukocyte elastase, Serum Amyloid P Component, C-X-C motif chemokine 6, Immunoglobulin A, Immunoglobulin G subclass I, C-C motif chemokine 24, Neutrophil collagenase, Cathepsin D, C-X-C motif chemokine 13, Involucrin, Interleukin-6 receptor subunit beta, Hepatocyte Growth Factor, CXCL-1, -2, -3, Immunoglobulin G subclass II, Metalloproteinase inhibitor 4, C-C motif chemokine 18, Matrilysin, C-X-C motif chemokine 11, and Antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient.
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