发明公开
EP2791111A1 PIPERIDINYL NAPHTHYLACETIC ACIDS
有权
[4-（PIPERIDIN-4-YL）-NAPHTHALEN-2-YL] - 维生素ALS CRTH2-ANTAGONISTEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN
- 专利标题： PIPERIDINYL NAPHTHYLACETIC ACIDS
- 专利标题（中）： [4-（PIPERIDIN-4-YL）-NAPHTHALEN-2-YL] - 维生素ALS CRTH2-ANTAGONISTEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN
-
申请号： EP12805511.8申请日： 2012-12-10
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公开(公告)号： EP2791111A1公开(公告)日： 2014-10-22
- 发明人: FIROOZNIA, Fariborz , LIN, Tai-An , MERTZ, Eric , SIDDURI, Achyutharao , SO, Sung-Sau , TILLEY, Jefferson Wright
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Schirlin, Julien
- 优先权： US201161569313P 20111212
- 国际公布： WO2013087544 20130620
- 主分类号： C07D211/18
- IPC分类号： C07D211/18 ; C07D211/96 ; A61K31/451 ; A61P11/00 ; A61P11/06 ; A61P11/08
摘要：
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R
1 , R
2 , R
3 and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
1 , R
2 , R
3 and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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