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公开(公告)号：EP2603500B1
公开(公告)日：2014-11-19
申请号：EP11746518.7
申请日：2011-08-09
发明人： BERTHEL, Steven, Joseph , BILLEDEAU, Roland, J. , BROTHERTON-PLEISS, Christine, E. , FIROOZNIA, Fariborz , GABRIEL, Stephen, Deems , HAN, Xiaochun , HILGENKAMP, Ramona , JAIME-FIGUEROA, Saul , KOCER, Buelent , LOPEZ-TAPIA, Francisco, Javier , LOU, Yan , ORZECHOWSKI, Lucja , OWENS, Timothy, D. , TAN, Jenny , WOVKULICH, Peter, Michael
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/10
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/107
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公开(公告)号：EP2603500A1
公开(公告)日：2013-06-19
申请号：EP11746518.7
申请日：2011-08-09
发明人： BERTHEL, Steven, Joseph , BILLEDEAU, Roland, J. , BROTHERTON-PLEISS, Christine, E. , FIROOZNIA, Fariborz , GABRIEL, Stephen, Deems , HAN, Xiaochun , HILGENKAMP, Ramona , JAIME-FIGUEROA, Saul , KOCER, Buelent , LOPEZ-TAPIA, Francisco, Javier , LOU, Yan , ORZECHOWSKI, Lucja , OWENS, Timothy, D. , TAN, Jenny , WOVKULICH, Peter, Michael
IPC分类号： C07D401/14 , C07D403/14 , C07D487/04 , C07D487/08 , C07D491/107 , A61K31/517
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/107
摘要： This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula (I): wherein, variables X, R, and Y
4 , are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.-
3.发明公开THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS 有权THIAZOLOPYRAMIDIN / PYRIDINHARNSTOFFDERIVATE拮抗剂腺苷2B受体
公开(公告)号：EP2027132A1
公开(公告)日：2009-02-25
申请号：EP07728869.4
申请日：2007-05-08
发明人： BRINKMAN, John A. , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , GUERTIN, Kevin Richard , MARCOPULOS, Nicholas , QI, Lida , RACHA, Jagdish Kumar , SARABU, Ramakanth , TAN, Jenny , TILLEY, Jefferson Wright
IPC分类号： C07D513/04 , C07D521/00 , A61K31/519 , A61K31/437 , A61P3/10
CPC分类号： C07D513/04 , C07D521/00
摘要： There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
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公开(公告)号：EP2731932B1
公开(公告)日：2015-12-30
申请号：EP12734923.1
申请日：2012-07-09
发明人： BILOTTA, Joseph Anthony , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , GUERTIN, Kevin Richard , HAYDEN, Stuart , HAYNES, Nancy-Ellen , LUKACS-LESBURG, Christine M. , MARCOPULOS, Nicholas , MERTZ, Eric , QI, Lida , QIAN, Yimin , SO, Sung-Sau , TAN, Jenny , THAKKAR, Kshitij Chhabilbhai
IPC分类号： C07D215/48 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D215/233 , A61K31/4709 , A61P3/10 , A61P19/00 , A61P35/00 , A61P25/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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5.发明授权THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS 有权噻唑并吡啶/吡啶尿素衍生物作为腺苷A2B受体拮抗剂
公开(公告)号：EP2027132B1
公开(公告)日：2010-09-15
申请号：EP07728869.4
申请日：2007-05-08
发明人： BRINKMAN, John A. , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , GUERTIN, Kevin Richard , MARCOPULOS, Nicholas , QI, Lida , RACHA, Jagdish Kumar , SARABU, Ramakanth , TAN, Jenny , TILLEY, Jefferson Wright
IPC分类号： C07D513/04 , C07D521/00 , A61K31/519 , A61K31/437 , A61P3/10
CPC分类号： C07D513/04 , C07D521/00
摘要： There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
摘要翻译： 提供了式（I）化合物，其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，或其药学上可接受的盐，它们是活性的腺苷A 2B受体拮抗剂并可用于治疗糖尿病，糖尿病 视网膜病，哮喘和腹泻。
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公开(公告)号：EP1791822A1
公开(公告)日：2007-06-06
申请号：EP05774995.4
申请日：2005-07-28
IPC分类号： C07D277/60 , C07D277/84
CPC分类号： C07D277/60 , C07D277/84 , C07D417/12 , C07D513/04
摘要： The invention is concerned with novel substituted N-acyl-2-aminothiazoles of the formula (I) wherein R, Ri and X are as defined in the specification and claims, as well as pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
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公开(公告)号：EP1963313A2
公开(公告)日：2008-09-03
申请号：EP06830027.6
申请日：2006-11-17
发明人： BOLIN, David Robert , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , HAMILTON, Matthew Michael , LI, Shiming , MCDERMOTT, Lee Apostle , QIAN, Yimin , YUN, Weiya
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/42 , A61P35/00
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
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公开(公告)号：EP2718264B1
公开(公告)日：2015-08-05
申请号：EP12725741.8
申请日：2012-06-04
IPC分类号： C07D213/34 , C07D213/71 , C07C311/20 , C07C311/29 , A61P11/00 , A61K31/18 , A61K31/44
CPC分类号： C07D213/34 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07C2602/12 , C07D213/71
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9.发明公开PIPERIDINYL NAPHTHYLACETIC ACIDS 有权[4-（PIPERIDIN-4-YL）-NAPHTHALEN-2-YL] - 维生素ALS CRTH2-ANTAGONISTEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN
公开(公告)号：EP2791111A1
公开(公告)日：2014-10-22
申请号：EP12805511.8
申请日：2012-12-10
发明人： FIROOZNIA, Fariborz , LIN, Tai-An , MERTZ, Eric , SIDDURI, Achyutharao , SO, Sung-Sau , TILLEY, Jefferson Wright
IPC分类号： C07D211/18 , C07D211/96 , A61K31/451 , A61P11/00 , A61P11/06 , A61P11/08
CPC分类号： C07D401/12 , C07D211/18 , C07D211/34 , C07D211/96
摘要： The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R
1 , R
2 , R
3 and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R1，R2，R3和X在详细说明书和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，并且可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP2731932A1
公开(公告)日：2014-05-21
申请号：EP12734923.1
申请日：2012-07-09
发明人： BILOTTA, Joseph Anthony , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , GUERTIN, Kevin Richard , HAYDEN, Stuart , HAYNES, Nancy-Ellen , LUKACS-LESBURG, Christine M. , MARCOPULOS, Nicholas , MERTZ, Eric , QI, Lida , QIAN, Yimin , SO, Sung-Sau , TAN, Jenny , THAKKAR, Kshitij Chhabilbhai
IPC分类号： C07D215/48 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D215/233 , A61K31/4709 , A61P3/10 , A61P19/00 , A61P35/00 , A61P25/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula (I): wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
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