发明公开
EP2798080A1 MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER
审中-公开
材料和诊断，预后，监测和评价癌症PANKREATOBILIÄREM用递推治疗性/预防性处理的方法
- 专利标题： MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER
- 专利标题（中）： 材料和诊断，预后，监测和评价癌症PANKREATOBILIÄREM用递推治疗性/预防性处理的方法
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申请号： EP12806870.7申请日： 2012-12-20
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公开(公告)号： EP2798080A1公开(公告)日： 2014-11-05
- 发明人: SOKOLOVA, Irina , MORRISON, Larry , PESTOVA, Ekaterina , FRITCHER, Emily, Barr , ROBERTS, Lewis , GORES, Gregory , HALLING, Kevin , KIPP, Benjamin
- 申请人： Abbott Molecular Inc. , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
- 申请人地址： 1300 East Touhy Avenue Des Plaines, IL 60018 US
- 专利权人： Abbott Molecular Inc.,MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
- 当前专利权人： Abbott Molecular Inc.,MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
- 当前专利权人地址： 1300 East Touhy Avenue Des Plaines, IL 60018 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US201161581810P 20111230
- 国际公布： WO2013101613 20130704
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.
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