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公开(公告)号：EP2798080B1
公开(公告)日：2019-02-20
申请号：EP12806870.7
申请日：2012-12-20
发明人： SOKOLOVA, Irina , MORRISON, Larry , PESTOVA, Ekaterina , FRITCHER, Emily, Barr , ROBERTS, Lewis , GORES, Gregory , HALLING, Kevin , KIPP, Benjamin
IPC分类号： C12Q1/6827 , C12Q1/6886
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2.发明公开MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER 审中-公开材料和诊断，预后，监测和评价癌症PANKREATOBILIÄREM用递推治疗性/预防性处理的方法
公开(公告)号：EP2798080A1
公开(公告)日：2014-11-05
申请号：EP12806870.7
申请日：2012-12-20
发明人： SOKOLOVA, Irina , MORRISON, Larry , PESTOVA, Ekaterina , FRITCHER, Emily, Barr , ROBERTS, Lewis , GORES, Gregory , HALLING, Kevin , KIPP, Benjamin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2537/16
摘要： A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.
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