发明公开
- 专利标题： 2-FLUOROPHENYLPROPIONIC ACID DERIVATIVE
- 专利标题（中）： 2-氟苯基丙酸衍生物
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申请号： EP12861106.8申请日： 2012-12-06
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公开(公告)号： EP2799424A1公开(公告)日： 2014-11-05
- 发明人: MIZUSHIMA, Toru , OTSUKA, Masami , OKAMOTO, Yoshinari , YAMAKAWA, Naoki
- 申请人： LTT Bio-Pharma Co., Ltd.
- 申请人地址： 2-20, Kaigan 1-chome Minato-ku Tokyo 105-0022 JP
- 专利权人： LTT Bio-Pharma Co., Ltd.
- 当前专利权人： LTT Bio-Pharma Co., Ltd.
- 当前专利权人地址： 2-20, Kaigan 1-chome Minato-ku Tokyo 105-0022 JP
- 代理机构： Beckmann, Claus
- 优先权： JP2011285854 20111227
- 国际公布： WO2013099553 20130704
- 主分类号： C07C59/135
- IPC分类号： C07C59/135 ; A61K31/192 ; A61K31/195 ; A61K31/341 ; A61K31/381 ; A61P29/00 ; C07C59/21 ; C07C229/40 ; C07C323/56 ; C07D307/54 ; C07D333/24
摘要：
Provided are novel 2-fluorophenyl propionic acid derivatives which have excellent anti-inflammatory/analgesic effects while avoiding side effects such as gastrointestinal disorders, namely 2-fluorophenyl propionic acid derivatives represented by the formula (I) below or pharmaceutically acceptable salts thereof,
[wherein, R 1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents -CH 2 -, -NH-, -O-, or -S-, and Y specifically represents group (II)
(wherein, Z 1 represents -CO-, -CH(OH)-, or -CH 2 -, and n represents an integer of 1 or 2.)]
[wherein, R 1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents -CH 2 -, -NH-, -O-, or -S-, and Y specifically represents group (II)
(wherein, Z 1 represents -CO-, -CH(OH)-, or -CH 2 -, and n represents an integer of 1 or 2.)]
公开/授权文献
- EP2799424B1 2-FLUOROPHENYLPROPIONIC ACID DERIVATIVE 公开/授权日：2016-08-17
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