- 专利标题： SILODOSIN INTERMEDIATE AND PREPARATION METHOD THEREFOR
-
申请号： EP12862614.0申请日： 2012-07-27
-
公开(公告)号： EP2801567A1公开(公告)日： 2014-11-12
- 发明人: ZHANG, Bin , HU, Xiaowei , YAN, Pucha , ZHANG, Xianyi , GAO, Hongjun , LI, Yuanqiang , CHE, Daqing
- 申请人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
- 申请人地址： 99 Waisha Road Jiaojiang District Taizhou City Zhejiang 318000 CN
- 专利权人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
- 当前专利权人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
- 当前专利权人地址： 99 Waisha Road Jiaojiang District Taizhou City Zhejiang 318000 CN
- 代理机构： Cremer, Karsten
- 优先权： CN201110440481 20111226
- 国际公布： WO2013097456 20130704
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; C07D209/04 ; C07D209/02 ; C07F7/18 ; C07F7/02 ; C07F7/00
摘要：
Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R 1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R 7 is an carboxyl-protecting group, and R 2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a hydroxyl-protecting group. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.
信息查询
